Daniel Jacoby Selected Research

Left Ventricular Outflow Obstruction

1/2022	Sarcomere protein modulation: The new frontier in cardiovascular medicine and beyond.
12/2021	Effect of Mavacamten on Echocardiographic Features in Symptomatic Patients With Obstructive Hypertrophic Cardiomyopathy.
12/2020	Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): a randomised, double-blind, placebo-controlled, phase 3 trial.
1/2019	Mavacamten Treatment for Obstructive Hypertrophic Cardiomyopathy: A Clinical Trial.
6/2014	Anomalous left coronary artery in hypertrophic cardiomyopathy.

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Daniel Jacoby Research Topics

Disease

17	Heart Failure 01/2022 - 02/2012
12	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 01/2022 - 01/2019
5	Left Ventricular Outflow Obstruction 01/2022 - 06/2014
4	Amyloidosis 06/2022 - 12/2016
4	Cardiomyopathies (Cardiomyopathy) 10/2021 - 02/2012
3	Weight Loss (Weight Reduction) 01/2020 - 07/2015
3	Atrial Fibrillation 01/2020 - 10/2018
3	Heart Arrest (Cardiac Arrest) 01/2020 - 10/2017
2	Cardiac Arrhythmias (Arrythmia) 01/2021 - 03/2014
2	Cardiovascular Diseases (Cardiovascular Disease) 06/2020 - 02/2017
2	Inflammation (Inflammations) 03/2020 - 01/2018
2	Sleep Initiation and Maintenance Disorders (Insomnia) 03/2020 - 05/2019
2	Fatigue 03/2020 - 05/2019
2	Cardiac Sudden Death (Sudden Cardiac Arrest) 01/2020 - 01/2020
2	Stroke (Strokes) 01/2020 - 10/2018
1	Pathologic Processes 06/2022
1	Obesity 12/2021
1	Pre-Eclampsia (Preeclampsia) 11/2021
1	Lymphopenia (Lymphocytopenia) 01/2021
1	Hypertension (High Blood Pressure) 06/2020
1	Mulibrey Nanism (Mulibrey Nanism Syndrome) 01/2020
1	Type 2 Diabetes Mellitus (MODY) 01/2020
1	Sleepiness 05/2019
1	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 04/2016
1	Renal Insufficiency (Renal Failure) 01/2016
1	Thrombosis (Thrombus) 01/2014
1	Sudden Death 02/2012
1	Disease Progression 11/2011

Drug/Important Bio-Agent (IBA)

9	MYK-461IBA 01/2022 - 01/2019
5	DiureticsIBA 01/2020 - 07/2015
4	Prealbumin (Transthyretin)IBA 06/2022 - 12/2016
4	Cardiac MyosinsIBA 01/2022 - 01/2019
3	Amyloid (Amyloid Fibrils)IBA 01/2019 - 12/2016
2	Proteins (Proteins, Gene)FDA Link 06/2022 - 10/2020
2	Biomarkers (Surrogate Marker)IBA 12/2021 - 03/2020
2	Brain Natriuretic Peptide (Natrecor)FDA Link 12/2021 - 01/2016
2	Myosins (Myosin)IBA 10/2020 - 01/2020
2	SodiumIBA 01/2020 - 01/2016
1	omecamtiv mecarbilIBA 01/2022
1	sulconazole (Myk)FDA Link 12/2021
1	P-2 (P 2)IBA 11/2021
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 06/2020
1	Hydrocortisone (Cortisol)FDA LinkGeneric 03/2020
1	Glucose (Dextrose)FDA LinkGeneric 01/2020
1	empagliflozinIBA 01/2020
1	Interleukin-6 (Interleukin 6)IBA 01/2018
1	MicroRNAs (MicroRNA)IBA 01/2017
1	CreatinineIBA 04/2016
1	ChloridesIBA 01/2016
1	Sodium Potassium Chloride Symporter Inhibitors (Loop Diuretics)IBA 01/2016
1	Platelet Aggregation Inhibitors (Antiplatelet Drugs)IBA 01/2014
1	GlycogenIBA 01/2014
1	Glycoproteins (Glycoprotein)IBA 01/2014
1	Biological ProductsIBA 02/2012

Therapy/Procedure

11	Therapeutics 01/2020 - 11/2011
5	Implantable Defibrillators (Implantable Cardioverter-Defibrillator) 10/2021 - 10/2018
3	Heart Transplantation (Grafting, Heart) 12/2021 - 10/2018
3	Heart-Assist Devices 01/2021 - 01/2014
2	Transplantation 12/2021 - 09/2013
1	Secondary Prevention 06/2020
1	Aftercare (After-Treatment) 05/2019
1	Precision Medicine 02/2017